In 1894 Susan La Flesche married Henry Picotte. (Her sister, Marguerite, married Henry’s brother, Charles!) Henry and Susan had two sons, Carl and Pierre. After her marriage, Susan settled with her husband at Bancroft, Nebraska and set up her own private practice, providing medical care for both Native and European Americans. At the same time, Dr. Picotte cared for her family, her ailing mother, and later, her ailing husband.